Krox-20 gene expression: Influencing hindbrain-craniofacial developmental interactions
نویسندگان
چکیده
منابع مشابه
Interactions between rhombomeres modulate Krox-20 and follistatin expression in the chick embryo hindbrain.
The rhombomeres of the embryonic hindbrain display compartment properties, including cell lineage restriction, genetic definition and modular anatomical phenotype. Consistent with the idea that rhombomeres are autonomous developmental units, previous studies have shown that certain aspects of rhombomere phenotype are determined early, at the time of rhombomere formation. By contrast, the apopto...
متن کاملKrox-20 is a key regulator of rhombomere-specific gene expression in the developing hindbrain
The morphogenesis of the vertebrate hindbrain involves a transient segmentation process leading to the formation of reiterated organisation units called rhombomeres (r). A number of regulatory genes expressed with a rhombomere-specific pattern have been identified, including the gene encoding the transcription factor Krox-20, which is restricted to r3 and r5. We have previously demonstrated tha...
متن کاملConserved segmental expression of Krox-20 in the vertebrate hindbrain and its relationship to lineage restriction.
The zinc-finger gene Krox-20 is expressed in two alternating segments, rhombomeres (r) 3 and 5, in the developing mouse hindbrain. This expression pattern is established prior to rhombomere formation in the mouse, but it is not known how the timing of expression relates to cellular events of segmentation, such as lineage restriction. We have cloned Krox-20 sequences from Xenopus and the chick a...
متن کاملSegmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20.
The hindbrain is a segmented structure divided into repeating metameric units termed rhombomeres (r). The Hox family, vertebrate homologs of the Drosophila HOM-C homeotic selector genes, are expressed in rhombomere-restricted patterns and are believed to participate in regulating segmental identities. Krox-20, a zinc finger gene, has a highly conserved pattern of expression in r3 and r5 and is ...
متن کاملSegmental and neuronal architecture of the hindbrain of Krox-20 mouse mutants.
The vertebrate hindbrain is transiently segmented during its early development with the formation of reiterated bulges, the rhombomeres (r). The Krox-20 gene, which encodes a zinc finger transcription factor, has been shown previously to be implicated in the maintenance of r3 and r5 (Schneider-Maunoury, S., Topilko, P., Seitanidou, T., Levi, G., Cohen-Tannoudji, M., Pournin, S., Babinet, C. and...
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ژورنال
عنوان ژورنال: Archives of Histology and Cytology
سال: 2005
ISSN: 0914-9465,1349-1717
DOI: 10.1679/aohc.68.227